米非司酮配伍米索前列醇对早孕蜕膜组织转化生长因子表达的影响

摘要

Objective:Through the research of mifepristone compatibility misoprostol therapy influenced the expression of transforming growth factor beta in early pregnancies decidual tissue,to discuss the function mechanism of termination of the early pregnancy therapy by mifepristone compatibility misoprostol. Methods:41 cases early pregnancy decidual tissue were collected from August 2010 to May 2011 in our hospital women outpatients,21 cases were divided into drug-abortion group,20 cases were divided into abortion group,then detected the expression of transforming growth factor beta.Results:The expression of drug-abortion group had statistically significant with abortion group(P<0.05),drug-abortion group expression was low,and had large difference of expression level. Conclusion:Mifepristone can reduce the expression of transforming growth factor beta,which can terminate pregnancy through the immune effect,misoprostol can enhance the effect or independent play the effect of termination of pregnancy.%　　目的：通过研究米非司酮配伍米索前列醇对早孕蜕膜组织转化生长因子表达的影响，探讨米非司酮配伍米索前列醇终止早孕的作用机制。方法：收集2010年8月-2011年5月在笔者所在医院终止妊娠的健康早孕妇女蜕膜组织41例，分为药流组21例和人流组20例，检测蜕膜组织中转化生长因子的表达水平。结果：药流组转化生长因子表达较低，与人流组比较，差异有统计学意义(P<0.05)。结论：米非司酮可以降低早孕蜕膜组织 TGF-β的表达，通过免疫效应达到终止妊娠的目的，米索前列醇增强或独立发挥了终止妊娠的效果。