抗抑郁治疗在糜烂性食管炎中的临床应用价值

摘要

目的：观察黛力新联合胃食管反流病(gastroesophageal reflux disease,GERD)标准治疗在质子泵抑制剂无效且伴有抑郁、焦虑的糜烂性食管炎(erosive esophagitis,EE)患者的临床疗效.方法：对按GERD标准正规治疗无效的44例EE患者在给予兰索拉唑、硫糖铝混悬凝胶及多潘立酮片常规治疗同时加服氟哌噻吨美利曲辛10.5 mg,1次/d,治疗6周后判定疗效.结果：治疗6周后,44例患者烧心、胸痛、反酸等症状均有明显减轻,治疗显效38例,有效4例,显效率为86.4%(38/44),总有效率为95.5%(42/44).结论：对质子泵抑制剂无效的伴抑郁与焦虑的糜烂性食管炎患者,联合黛力新治疗,可快速减轻糜烂症状,改善患者的抑郁与焦虑,值得推广.%Objective:To observe the clinical effect of the treatment for patients,who had erosive esophagitisdisease (EE) associated with depression and anxiety with proton pump inhibitor treatment failures,using Lansoprazole united Deanxit.Methods:44 patients with EE were given additionally Deanxit (10.5 mg, once a day)for 6 weeks with general treatment.Results:All patients recovered and the treatment rate of the 44 patients was 86.4%(38/44),with the total effective rate of 95.5%(42/44).Conclusion:Deanxit joint anti-reflux treatment can quickly relieve reflux symptoms and improve the patient’s depression and anxiety,it should be recommended.