β受体阻滞剂在心力衰竭中的作用

摘要

目的：研究β受体阻滞剂在心力衰竭及心律失常中的临床治疗作用。方法：选取笔者所在医院2012年1-12月收治的324例慢性心力衰竭患者作为研究对象，采用随机抽签法将其分为对照组和A、B组各108例，对照组给予安慰剂治疗，A组给予美托洛尔治疗，B组给予卡维地洛治疗，观察比较三组患者的死亡情况和再住院情况。结果：治疗8周后，A组的猝死率、心衰死亡率、心血管死亡率、总死亡率和再住院率分别为9.26%、8.33%、8.33%、28.70%、22.22%；B组为2.78%、1.85%、1.85%、7.41%、12.04%，两组各观察指标均明显低于对照组，且B组以上指标均明显低于A组，差异均有统计学意义(P<0.05)。结论：β受体阻滞剂在治疗心力衰竭和心律失常中具有降低死亡率和再住院率的优点，但不同类型β受体阻滞剂治疗效果存在一定差异，在临床用药过程中要综合考虑，合理用药。%Objective:To research the clinical effect ofβ-blockers in heart failure and arrhythmia.Method:324 patients with chronic heart failure admitted to our hospital from January 2012 to December 2012 were selected,they were divided into the control group,the group A and the group B with the method of random sampling,108 cases in each group.The control group was given Placebo for treatment,the group A was given Metoprolol for treatment,the group B was given Carvedilol for treatment.The death and readmission of the three groups were observed and compared.Result:After 8 weeks of treatment,the sudden death,heart failure caused mortality,cardiovascular mortality,total mortality and readmission rates in group A were 9.26%,8.33%,8.33%,28.70%, 22.22%,those in the group B were 2.78%,1.85%,1.85%,7.41%,12.04%.The observed indices of two groups were significantly lower than the control group, and the above indexes of group B were significantly lower than group A,the differences were statistically significant(P<0.05).Conclusion:β-blockers has the advantage of reducing mortality and readmission rates in the treatment of heart failure and cardiac arrhythmias,but there are some differences between different types ofβ-blocker treatment,in the clinical course of medication to be considered,rational drug use.