腺性膀胱炎患者血清中细胞因子IL-2、IFN-γ、TNF-α的研究

摘要

Objective:To investigate the role of the cytokines IL-2,IFN-γ,TNF-αin cystitis glandularis occurred. Method:Selected the author’s hospital treated by cystoscopy and biopsy was confirmed pathologically as cystitis gland sex as experimental group of 30 cases,alternate period health check-up 30 cases as control group,through the detection of the expression levels of two groups of patients with serum IL-2,IFN-γ,TNF-αcytokine,and expression level in the patients with cystitis glandularis after 3 months of treatment the serum levels of IL-2,IFN-γ,TNF-αcytokine,make statistical analysis. Result:Treatment group 28 cases effective,2 cases had no effect,the effective rate was 93.3%. Patients serum cytokine IL-2,IFN-gamma,TNF alpha were significantly higher than that of control group,the difference was statistically significant (P<0.05). But the experimental group before and after treatment serum cytokine IL-2,IFN-gamma,TNF alpha comparison difference had no statistical significance (P>0.05).Conclusion:Cytokines in the gland sex cystitis plays an important role;cutting and bladder perfusion chemotherapy drugs in treatment of glandular cystitis method does not change cytokines in serum IL-2,IFN-γ, TNF-αlevel,patients need long-term follow-up.%目的：探讨细胞因子IL-2、IFN-γ、TNF-α在腺性膀胱炎发生中的作用。方法：选取笔者所在医院收治的通过膀胱镜检查及活组织病理检查证实为腺性膀胱炎的30例患者设为试验组，另选同期健康体检者30例设为对照组，通过检测两组患者血清中IL-2、IFN-γ、TNF-α细胞因子的表达水平，以及腺性膀胱炎患者治疗3个月后血清中IL-2、IFN-γ、TNF-α细胞因子的表达水平，做出统计分析。结果：试验组有效28例，无效2例，有效率93.3%。治疗前后试验组血清中细胞因子IL-2、IFN-γ、TNF-α均明显高于对照组，差异有统计学意义(P<0.05)。但试验组治疗前后血清中细胞因子IL-2、IFN-γ、TNF-α比较差异无统计学意义(P>0.05)。结论：细胞因子在腺性膀胱炎的发生中起着重要作用；电切加化疗药物膀胱灌注治疗腺性膀胱炎的方法并不能改变患者血清中细胞因子IL-2、IFN-γ、TNF-α水平，患者需要长期随访。