新生儿细菌感染性疾病的病原菌分布及药敏分析

摘要

Objective:To analyze the distribution of pathogenic bacteria of neonatal bacterial infection disease and drug sensitivity status.Method:420 newborn with infection of sputum,blood,swabs and umbilical discharge specimens were included in the study,420 cases of specimens were cultured and analyzed the results of antibiotic sensitivity of bacteria.Result:A total of 488 infected specimens,288 strains of bacteria were isolated,including 147 strains(51.0%) of gram negative bacteria,including Escherichia coli,Klebsiella pneumoniae,Enterobacter cloacae,the rates were 39.5%,28.6%,8.2%,a higher sensitivity of drugs in imipenem,Amikacin,cephalosporins.Gram positive bacteria,including 141 strains(49.0%),Staphylococcus epidermidis,Staphylococcus aureus, Staphylococcus haemolyticus,rates were 19.9%,26.9%,12.1%,a higher sensitivity of drugs in vancomycin,penicillin,etc.Conclusion:The clinical treatment of neonatal bacterial infection should be targeted to select antimicrobial susceptibility.%目的：分析新生儿细菌感染性疾病中的病原菌分布及药敏状况。方法：选取420例感染新生儿的痰液、血液、咽拭子及脐分泌物等标本纳入研究，对420例标本进行培养，并对细菌药敏结果进行分析。结果：本次共488份感染标本送检，共分离288株细菌，其中革兰阴性菌147株(51.0%)，包括大肠埃希菌、肺炎克雷伯菌、阴沟肠杆菌，比例分别为39.5%、28.6%、8.2%，敏感性较高的药物有亚胺培南、阿米卡星、头孢类等；革兰阳性菌141株(49.0%)，包括表皮葡萄球菌、金黄色葡萄球菌、溶血葡萄球菌，比例分别为19.9%、26.9%、12.1%，敏感性较高的药物事万古霉素、青霉素等。结论：临床治疗新生儿细菌性感染时宜针对性选择敏感性抗菌药物。