重症细菌感染患者应用降钙素原、C反应蛋白诊疗的临床分析

摘要

目的：探讨重症细菌感染患者应用降钙素原、C反应蛋白诊疗的临床分析。方法：将2013年9月-2014年9月在笔者所在医院内科治疗的30例重症细菌感染患者作为观察组，将同期30例无感染的正常者作为对照组，均检测两组的降钙素原、C反应蛋白水平，并对结果进行比较。结果：观察组的PCT、CRP浓度较对照组均明显升高，观察组的PCT阳性率93.33%和CRP阳性率70.00%均明显高于对照组的13.33%和20.00%，差异均有统计学意义(P<0.05)。与治疗前相比，观察组治疗48 h、72 h、出院前的PCT、CRP均明显下降，差异均有统计学意义(P<0.05)。结论：降钙素原、C反应蛋白灵敏度高，特异性强，能够快速明确诊断，在重症细菌感染中应用有积极的临床意义。%Objective:To investigate the clinical analysis of application of procalcitonin,C-reactive protein in the diagnosis and treatment of patients with severe bacterial infection.Method:30 patients with severe bacterial infection in department of internal medicine of our hospital from September 2013 to September 2014 were selected as the observation group,30 patients with no infection were selected as the control group,the procalcitonin,C reactive protein level of the two groups were detected and compared.Result:The PCT and CRP concentration of the observation group were significantly increased compared with the control group,the differences were statistically significant(P<0.05).The positive rate of PCT and CRP in the observation group were 93.33%and 70.00%,which were significantly higher than 13.33%and 20.00%in control group,the differences were statistically significant(P<0.05).Compared with before treatment,the PCT,CRP at treatment 48 h,treatment 72 h,before discharge were significantly decreased, the differences were statistically significant(P<0.05).Conclusion:Procalcitonin and C-reactive protein have high sensitivity,specificity,can quickly clear diagnosis,application in severe bacterial infection with positive clinical significance.