兰索拉唑与奥美拉唑治疗酒精型消化性溃疡的临床对照研究

摘要

Objective:To investigate the clinical efficacy of Lansoprazole and Omeprazole on alcoholic peptic ulcer.Method:160 patients with alcoholic peptic ulcer in our hospital from January 2013 to December 2014 were randomly divided into the observation group and the control group,80 cases in each group.80 cases in the control group were treated with Omeprazole,Clarithromycin and Amoxicillin.The observation group were treated with Lansoprazole, Clarithromycin and Amoxicillin.The clinical efficacy,adverse reactions and Hp clearance rate of two groups were compared.Result:The clinical total effective rate in observation group was 96.3%,was significantly higher than 88.8% in the control group,the difference was statistically significant(P<0.05).Hp eradication in the observation group was 93.8%,was significantly higher than 81.3% in the control group,the difference was statistically significant(P<0.05).There were varying degrees of adverse reactions occurred during treatment in both groups,but patients could tolerate,significant liver and kidney dysfunction did not occur.The incidence of adverse events of two group were statistically significant(P<0.05).Conclusion:The clinical efficacy of Lansoprazole and Omeprazole on alcoholic peptic ulcer is curative effect and low adverse reactions in the clinical application.%目的：研究兰索拉唑联合抗生素治疗酒精型消化性溃疡的临床效果。方法：选择2013年1月-2014年12月于笔者所在医院消化内科就诊的酒精型消化性溃疡患者160例，采用随机数字表法将患者分为观察组和对照组，每组各80例。两组患者均给予克拉霉素0.5 g+阿莫西林0.1 g，口服，2次/d。在上述治疗基础上，观察组患者给予兰索拉唑30 mg，早晨空腹服用，1次/d。对照组患者给予奥美拉唑20 mg，口服，2次/d。疗程均为4周。比较两组患者临床疗效、不良反应及Hp清除率。结果：观察组临床总有效率为96.3%，显著高于对照组的88.8%，差异有统计学意义(P<0.05)。观察组Hp根除率为93.8%，显著高于对照组的81.3%，差异有统计学意义(P<0.05)。两组治疗期间均有不同程度的不良反应发生，但患者均可耐受，未发生明显肝肾功能损害。观察组不良反应发生率显著低于对照组，差异有统计学意义(P<0.05)。结论：兰索拉唑治疗酒精型消化性溃疡临床效果确切，Hp根除率高，且不良反应低，值得在临床推广应用。