甲巯咪唑与丙基硫氧嘧啶对比治疗甲状腺功能亢进症的系统评价

摘要

目的：对比分析甲巯咪唑与丙基硫氧嘧啶治疗甲状腺功能亢进症的临床效果。方法：选取2013年1月-2014年12月来笔者所在医院进行治疗的甲状腺功能亢进症患者98例，按照治疗方式分为观察组(n=50)和对照组(n=48)。观察组口服甲巯咪唑，对照组口服丙基硫氧嘧啶进行治疗，对比分析两组患者治疗效果。结果：两组患者治疗1、2、3个月后FT3和FT4水平与治疗前相比均显著降低，sTSH水平升高(P<0.05)；但观察组患者FT3和FT4降低幅度及sTSH水平升高幅均显著优于对照组(P<0.05)。两组患者不良反应发生率相当(P>0.05)。结论：与丙硫氧嘧啶相比，甲巯咪唑在改善甲亢患者FT3、FT4和sTSH甲状腺激素方面的效果显著较优，且两者不良反应发生情况相当，建议在临床治疗普通甲亢患者的过程中，可优先考虑甲巯咪唑。%Objective:To compare the treatment of hyperthyroidism and the effect between using A Sulfhydryl Imidazole and Propylthiouracil. Method:Ninty-eight hyperthyroidism patients were chosen in our hospital from January 2013 to December 2014,according to the treatment way they were divided into two groups,the observation group(n=50) and the control group(n=48).A Sulfhydryl Imidazole was giving to the observation group,and Propylthiouracil was giving to the control group.Then contrastive and analyzing the effects of two groups.Result:After treated about three months,two groups patients’ FT3 and FT4 compared with no treatment’s time had a significant reduction,the standard of the sTSH also all rising significant(P<0.05).But the same thing ranges happened in the observation group was higer than that in the control group(P<0.05).But the occurrence rates of untoward affection’s had no differ to two groups(P>0.05). Conclusion:Comparing with Propylthiouracil,A Sulfhydryl Imidazole has a significant effect on improving the hyperthyroidism patients in FT3,FT4 and sTSH. And the occurrence rate of untoward affection between two drugs without too much difference.In the process of treating ordinary hyperthyroidism patients,A Sulfhydryl Imidazole should be used at first.