目的探讨奥氮平联合文拉法新治疗甲基苯丙胺所致精神障碍的疗效及安全性，以及重复滥用情况分析。方法42例甲基苯丙胺所致精神障碍的患者随机分为研究组（奥氮平联合文拉法新治疗）对照组（奥氮平治疗组）疗程6周，六个月随访。采用BPRS量表评定严重程度，TESS评定药物不良反应。同时监测血常规，肝功能，心电图。结果治疗结束时两组疗效为研究组91.8%，对照组64.6%，两组疗效差异有统计学意义（p<0.05）药物不良反应差异无统计学意义(p>0.05)六个月随访重复滥用情况研究组为8.4%，对照组为24.7%。结论奥氮平联合文拉法新治疗甲基苯丙胺所致精神障碍与单用奥氮平相比疗效更好，且安全，可预防重复滥用。%Objective To investigate the efficacy and safety of olanzapine combined with the mental disorder induced by methamphetamine venlafaxine treatment, and repeated abuse analysis. Methods: 42 cases of methamphetamine induced mental disorder were randomly divided into study group (olanzapine combined with venlafaxine in treatment group (treatment group) and olanzapine) treatment for 6weeks, to evaluate severity by BPRS, TESS assessment of adverse drug reaction. While monitoring the blood routine, liver function, electrocardiogram. Results: after the treatment efficacy of the two groups as study group 91.8%, control group 64.6%, two groups was statistically significant difference (p<0.05) with no significant difference in adverse drug reaction (p>0.05) six months after repeated abuse research group was 8.4%, control group 24.7%. Conclusion: olanzapine combined with venlafaxine in treatment of methamphetamine induced mental disorder and single olanzapine is better efficacy, and safe, can prevent repeated abuse.
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