N-乙酰半胱氨酸治疗氯米芬抵抗多囊卵巢综合征的效果评价

摘要

Objective:To explore the clinical effect of N-acetylcysteine in the treatment of clomiphene resistant polycystic ovary syndrome.Methods:40 patients with clomiphene resistant polycystic ovary syndrome were selected.They were randomly divided into the observation group and the control group with 20 cases in each.The control group was given oral stimulate ovulation medicine at menses or fifth day of retreat hemorrhages,taking for 5 days,and given folic acid,clomiphene 5mg one day.The observation group was given oral NAC 1.8~3.0 g one day.The two groups were used for 5 to 6 weeks.The clinical effects of two groups were observed.Results:In the observation group,the endometrial thickness was (7.81 ± 1.20)mm,17 cases(85.0% ) had mature follicle development,16 cases(80.0%) had ovulation,13 cases(65.0%) had pregnancy.In the control group,the endometrial thickness was (9.01±2.01)mm,13 cases(65.0%) had mature follicle development,9 cases(45.0%) had ovulation,2 cases(10.0%) had pregnancy.The difference between the two groups was statistically significant(P<0.05).The control group had 2 cases of adverse reaction,the adverse reaction incidence rate was 10%.The observation group showed no adverse reaction.The difference was statistically significant between the two groups(P<0.05).Conclusion:N-acetylcysteine in the treatment of clomiphene resistant polycystic ovary syndrome has a significant curative effect,greatly increases the pregnancy rate.%目的：探讨N-乙酰半胱氨酸治疗氯米芬抵抗多囊卵巢综合征的临床效果。方法：收治氯米芬抵抗多囊卵巢综合征患者40例，随机分为观察组和对照组各20例。对照组均在月经来潮或撤退性出血第5天口服促排卵药，连服5 d，同时给予叶酸、氯米芬5 mg/d。观察组口服NAC 1.8～3.0 g/d，两组均连用5～6周。观察两组的临床效果。结果：观察组子宫内膜厚度(7.81±1.20)mm，成熟卵泡发育17例(85.0%)，排卵16例(80.0%)，妊娠13例(65.0%)；对照组子宫内膜厚度(9.01±2.01)mm，成熟卵泡发育13例(65.0%)，排卵9例(45.0%)，妊娠2例(10.0%)。两组比较，差异具有统计学意义(P＜0.05)。对照组不良反应2例，不良反应发生率10.0%，观察组未见不良反应，两组比较，差异有统计学意义(P＜0.05)。结论：N-乙酰半胱氨酸治疗氯米芬抵抗多囊卵巢综合征具有显著疗效，大大提高了受孕率。