妊娠期肝内胆汁淤积症对妊娠围产结局影响的临床分析

摘要

Objective:To explore the influence of intrahepatic cholestasis syndrome at gestation period for perinatal outcome of pregnancy.Methods:97 patients with intrahepatic cholestasis syndrome at gestation period were selected as the observation group.90 pregnant woman without intrahepatic cholestasis syndrome were selected as the control group.We compared two groups of pregnancy outcome.Results:We compared postpartum hemorrhage rate,the rate of cesarean section,direct bilirubin average value,average value of the average value of total bilirubin,aspartate aminotransferase mean value,alanine aminotransferase mean value and total bile acid average value of the two groups,and the differences were statistically significant(P<0.05).In the observation group,the incidence of low birth weight infants,preterm birth rate,neonatal asphyxia,intrauterine fetal death,amniotic fluid pollution more than or equal to the second degree,fetal intrauterine distress incidence were significantly higher than those of the control group(P<0.05).Conclusion:Pregnancy outcome of intrahepatic cholestasis syndrome at gestation period was bad.It had great harm to both mother and child.Therefore,in clinical practice,we should pay more attention to the prevention and treatment of the disease.%目的：讨论妊娠期肝内胆汁淤积症对妊娠围产结局的影响。方法：收治妊娠期肝内胆汁淤积症患者97例为观察组，收治非肝内胆汁淤积症孕妇90例为对照组，比较两组的妊娠结局。结果：两组孕妇在产后出血率、剖宫产率、直接胆红素平均值、总胆红素平均值、谷草转氨酶平均值、谷丙转氨酶平均值和总胆汁酸平均值方面比较，差异均有统计学意义(P＜0.05)；观察组在低体重儿发生率、早产率、新生儿窒息率、宫内死胎、羊水污染≥Ⅱ度及胎儿宫内窘迫发生率均明显高于对照组(P＜0.05)。结论：妊娠期肝内胆汁淤积症具有不良的妊娠结局，对母婴都会造成比较大的危害，因此在临床实践中应该重视该疾病的预防和治疗。