普通肝素与低分子肝素治疗抗磷脂抗体阳性复发性流产疗效的Meta分析

摘要

目的：探讨普通肝素与低分子肝素治疗抗磷脂抗体阳性复发性流产的疗效。方法：采用Cochrane协作网系统评价方法，对有关普通肝素与低分子肝素治疗抗磷脂抗体阳性复发性流产研究进行质量评价。结果：低分子肝素组的胎儿流产风险是普通肝素组的0.59倍；低分子肝素组治疗复发性流产妇女最终导致其并发症的发生风险是普通肝素组的1.34倍，但差异均无统计学意义(P＞0.05)。结论：普通肝素与低分子肝素治疗抗磷脂抗体阳性复发性流产的临床疗效无差异。%Objective:To investigate the efficacy of common heparin and low molecular heparin in the treatment of anti phospholipid antibody positive recurrent spontaneous abortion.Methods:We adopted the cochrane cooperative network system evaluation method,to do the quality evaluation of the common heparin and low molecular heparin in the treatment of anti phospholipid antibody positive recurrent spontaneous abortion.Results:Low molecular heparin group fetal risk of miscarriage is unfractionated heparin group 0.59 times;low molecular weight heparin group treatment of women with recurrent spontaneous abortion ultimately lead to the complication risk is unfractionated heparin group of 1.34 times,but the difference was not statistically significant (P>0.05).Conclusion:There is no difference between the clinical efficacy of ordinary heparin and low molecular heparin in the treatment of anti phospholipid antibody positive recurrent miscarriage.