西格列汀联合单一口服药治疗2型糖尿病观察

摘要

Objective:To explore the clinical curative effect and reliability of sitagliptin combined treatment of type 2 diabetes with single oral medicine poor treatment effect.Methods:60 patients with type 2 diabetes were selected from April 2013 to April 2014.The patients were randomly divided into the observation group and the control group with 30 cases in each according to the admission number.The control group was given single oral medicine metformin treatment.The observation group was given combined sitagliptin treatment on the basis of the control group.The treatment effects of patients in two groups were compared. Results:After the patients in two groups received 10 weeks treatment,the BMI,fasting blood glucose,diet after 2 hours blood glucose,HbA1C and the incidence rate of hypoglycemia of the control group were significantly decreased than before treatment,The above index of the observation group were significantly decreased than before treatment.The diet after 2 hours C peptide and fasting C peptide of patients in two groups were compared,there was no statistical significance(P>0.05).After 10 weeks treatment, the BMI,fasting blood glucose,diet after 2 hours blood glucose,HbA1C of the observation group and the control group were compared with a significant difference(P<0.05).Conclusion:In the treatment of type 2 diabetes,it can use sitagliptin combined single oral medicine treatment methods.It can effectively improve the treatment effect of patients,and improve the prognosis quality.It is worth popularizing in clinic.%目的：探讨西格列汀联合单一口服药治疗2型糖尿病的临床疗效与可靠性。方法：2013年4月-2014年4月收治2型糖尿病患者60例，将患者按照入院编号随机分为观察组和对照组，各30例。对照组给予单一口服药二甲双胍治疗；观察组在对照组的基础上，再联合采用西格列汀治疗，比较两组患者的治疗效果。结果：两组患者在接受10周治疗后，对照组体重指数、空腹血糖、饮食后2 h的血糖、HbA1C以及低血糖发生率等指标与治疗前相比明显下降，观察组以上指标较治疗前明显下降。两组患者饮食2 h后C肽和空腹C肽对比，差异无统计学意义(P＞0.05)。10周治疗后，观察组和对照组患者体重指数、空腹血糖、饮食后2 h的血糖、HbA1C比较差异具有统计学意义(P＜0.05)。结论：在治疗2型糖尿病时，可以采用西格列汀联合单一口服药治疗的方法，能有效改善患者治疗效果，提高预后质量，值得在临床上大力推广。