胃肠道间质瘤76例的临床病理及免疫组织化学特征

摘要

目的：探讨胃肠道间质瘤的临床病理特征与免疫组织学特征。方法：收治GIST患者76例，先后进行临床病理检查及免疫组织学检查，分析其临床病理特征与免疫组织学特征。结果：GIST 常见发病位置有肠系膜、腹膜后、结肠、小肠以及胃部；间质瘤在显微镜下多为梭形细胞，其余有上皮样细胞或混合型细胞；a-SMA 多为局部阳性， CD34、DOG-1以及CD117等多为弥漫强阳性。结论：高发于中老年群体的GIST在病理学上具有细胞多态性特征， CD117可广泛表达GIST细胞，可为GIST的诊断指标。%Objective:To investigate the clinicopathologic features and immunohistochemical features of gastrointestinal stromal tumors.Methods:76 cases of GIST were selected.The clinical pathological examination and immunohistochemical examination were carried out,then we analyzed their clinical pathological characteristics and immunohistochemical features.Results:Mesenteric,retroperitoneal,colon,small intestine and stomach were the common onset location of GIST,stromal tumor under the microscope majority spindle cells,and the rest were epithelioid cells or hybrid cells;a-SMA for partial positive,and the CD34, DOG-1 and CD117 was diffuse and strong positive.Conclusion:GIST has high incidence in the middle aged and elderly population.It has the characteristics of cell polymorphism in pathology.CD117 can be widely expressed in GIST cells,which can be used for the diagnosis of GIST.