大环内酯类抗生素的不良反应分析

摘要

目的：分析大环内酯类抗生素的不良反应。方法：回顾性分析大环内酯类抗生素不良反应42例的临床资料。结果：42例患者中皮肤过敏、肠胃系统反应发生率较高。皮肤过敏反应发生率47.62%，肠胃系统反应发生率21.19%。大环内酯类抗生素老品种不良反应发生率明显高于新品种，差异具有统计学意义(P＜0.05)。老品种不良反应中过敏性休克、皮肤过敏、肠胃系统以及血栓性静脉炎发生率明显高于新品种，差异具有统计学意义(P＜0.05)，新品种肝损害不良反应发生率明显高于老品种(P＜0.05)。结论：大环内酯类抗生素引起的不良反应类型中皮肤过敏、肠胃系统反应发生率相对较高，且新品种的不良反应发生率低于老品种。%Objective:To analyze the adverse reactions of macrolide antibiotics.Methods:The clinical data of 42 cases of patients with adverse reactions of macrolide antibiotics were analyzed retrospectively.Results:The occurrence rates of skin allergy and gastrointestinal reaction in 42 cases of patients were higher.The incidence of skin allergic reaction was 47.62%and the incidence of gastrointestinal system reaction was 21.19%.The adverse reactions incidence of the old varieties of macrolide antibiotics was significantly higher than that of the new varieties,and the difference was statistically significant(P<0.05).The incidence of allergic shock,skin allergy,gastrointestinal reaction and thrombotic phlebitis in the adverse reaction of old varieties were significantly higher than that of new varieties,and the differences were statistically significant(P<0.05).The adverse reaction incidence of liver damage in the new varieties was significantly higher than that of old varieties(P<0.05).Conclusion:The incidence of skin allergy and gastrointestinal reactions in the adverse reaction caused by macrolide antibiotics were relatively higher and the incidence of adverse reactions of the new varieties was lower than that of the old varieties.