免疫组化p16、Ki-67在宫颈上皮内瘤变病理的诊断价值

摘要

Objective:To discuss the diagnostic value of tumor change pathology of immunohistochemical p16 and Ki-67 in cervical epithelium.Method:100 patients with cervical intraepithelial neoplasia were selected,they were divided into the mild cervical intraepithelial neoplasia(the CINⅠ group),the moderate cervical intraepithelial neoplasia(the CINⅡ group),the severe cervical intraepithelial neoplasia(the CINⅢ group).Another 35 cases of cancer patients were choosed as the cancer group.They were all measured with the method of testing and observed the changes of P16 and Ki-67 in the body.Results:After testing of four groups,the positive rates of P16 were 98.42%,90.89%,86.42% and 1.74%,the positive rates of Ki-67 were 98.9%,99.3%,99.5%and 28.4% .There were significant differences among the positive indicators of four groups,P<0.05 the differences were statistically significant.Conclusion:p16 and Ki-67 are closely related to the case rates of cervical diseases.And the higher the index,the higher the patients'' case rates,the patients'' condition is more serious.The index test has certain positive significance for the treatment of patients with cervical disease.%目的:探讨免疫组化p16、Ki-67在宫颈上皮内瘤变病理的诊断价值.方法:收治宫颈上皮内瘤病变患者100例,分为轻度宫颈上皮内瘤患者(CINⅠ组)、中度宫颈上皮内瘤患者(CINⅡ组)、重度宫颈上皮内瘤患者(CINⅢ组),另外选取癌症患者35例作为癌症组,均对其运用化验的方式进行测量,并且观察其体内的P16及Ki-67指标变化的状况.结果:4组检测患者经过化验后,其P16的阳性率分别为:98.42%、90.89%、86.42%、1.74%;Ki-67的阳性率分别为 98.9%、99.3%、99.5%、28.4%.4 组检测患者的阳性指标存在明显差异,P<0.05,差异有统计学意义.结论:p16及Ki-67与患者宫颈疾病的患病率有着密切的关系,并且指标越高,患者的患病率则越高,病情更加严重.指标化验对于宫颈疾病患者的治疗具有一定的积极意义.