FOLFOX 6方案联合腹部内生场热疗治疗晚期大肠癌的临床研究

摘要

Objective To evaluate the effect and adverse reaction of FOLFOX 6 regimen combined with abdominal endogeny heat therapy on advanced colorectal cancer.Methods Thirty-nine cases in control group were treated by FOLFOX 6 regimen: oxaliplatin 85mg/m2 iv over 2h on d1; leucovorin 200mg/m2 iv over 2h on d1; fluorouracil( 5-FU ) 400mg/m2 iv bolus on d1 ,and then followed by total 2400mg/m2 over 46h continuous infusion.Two weeks was a cycle.Thirty-nine cases in treatment group were treated by FOLFOX6 regimen( the same as control group) combined with abdominal endogeny heat therapy: 1h after 5-FU on d1 and d8 in each cycle.After 4 cycles of treatment effect and adverse reaction were evaluated.Results In treatment group, the overall response rate( CR + PR)was 56.41％, and median TTP was 9.5 months; while in control group CR + PR was 41.03 ％, and median TTP was 8.6 months.The overall response rate in treatment group was slightly higher than that in control group.However, there was no significant difference between the two groups (P =0.174, P =0.812).Nervous system toxicity in treatment group was significantly reduced compared with that in control group, especially in acral paresthesia and facial paresthesia, with statistical significant differences ( P = 0.023, P=0.039).Conclusion The FOLFOX 6 regimen combined with abdominal endogeny heat therapy for advanced colorectal cancer is better in efficacy and lower in adverse reaction.%目的 评价FOLFOX 6方案联合腹部内生场热疗治疗晚期大肠癌的疗效和不良反应.方法 对照组39例采用FOLFOX 6方案:奥沙利铂100mg/m2 静滴2小时,第1天;亚叶酸钙(CF)200mg/m2静滴2小时,第1天;氟尿嘧啶(5-FU)400mg/m2静推,第1天,然后总量2400mg/m2持续静滴46小时;每2周重复1次.试验组39例采用FOLFOX 6方案化疗的同时(剂量和方法同对照组),每周期第1天(5-FU静滴后1小时)、第8天分别进行腹部内生场热疗1小时.4周期治疗结束后评价疗效和毒副反应.结果 试验组有效率(CR+PR)为56.41%,中位肿瘤进展时间(TTP)为9.5个月;对照组有效率为41.03%,中位TTP为8.6个月,试验组略优于对照组,但两组差异无统计学意义(P值分别为0.174和0.812).试验组神经系统毒性较对照组明显减轻,尤其是肢端感觉异常及面部感觉异常,两组差异有统计学意义(P值分别为0.023和0.039).结论 FOLFOX 6方案联合腹部内生场热疗治疗晚期大肠癌的疗效好,毒副作用少.