弥漫大B细胞淋巴瘤患者血清乳酸脱氢酶、β2-微球蛋白联合检测的临床意义∗

摘要

Objective To investigate the clinical significance of serum levels of lactate dehydrogenase( LDH) andβ2⁃micro⁃globulin(β2⁃MG) in diffuse large B⁃cell lymphoma(DLBCL). Methods The serum levels of LDH and β2⁃MG of 58 patients with DLBCL were measured by rate method and radioimmunoassay. Besides, the clinicopathological characteristics of the patients such as gender, age, B symptoms, clinical stages, ECOG score of performance status( ECOG⁃PS) and bone marrow invasion were summarized and anylyzed. Meanwhile, the association between the level change of LDH and β2⁃MG after chemotherapy and therapeutic effectiveness was also evaluated. Results The levels of LDH andβ2⁃MG in the advanced stage group,ECOG≥2 group, bone marrow invasion group were significantly higher than those of their counterpart (P<0�05).The level of β2⁃MG in aged over 60 patients was higher than that of younger ones ( P<0�05) ,but there was no statistical significance in the LDH level( P>0�05) . The level of LDH in B symptoms group was higher than that of without B symptoms( P<0�05) ,but there was no statistical significance in the β2⁃MG level ( P>0�05) . There was no statistical significance about LDH andβ2⁃MG levels in gender( P>0�05) . The levels of LDH andβ2⁃MG in positive response group significantly decreased after chemotherapy ( P<0�05) . Conclusion LDH andβ2⁃MG can be taken as indica⁃tors in classifying the clinical phase and judging whether there is bone marrow infiltration or not, and evaluating the chemotherapeutic effectiveness of DLBCL patients.%目的探讨血清乳酸脱氢酶（ LDH ）、β2⁃微球蛋白（β2⁃MG ）水平的联合检测对弥漫大 B 细胞淋巴瘤（ DLBCL）的临床意义。方法选择2009年1月至2014年6月我院收治的初治DLBCL患者58例，分别采用速率法和放射免疫分析法检测血清LDH和β2⁃MG表达水平，并分析其与DLBCL临床病理特征的关系；同时观察化疗有效组患者治疗前后LDH和β2⁃MG表达水平的变化，评价其与疗效的关系。结果 LDH和β2⁃MG水平在Ⅲ～Ⅳ期、ECOG评分≥2以及有骨髓浸润的患者中均明显升高（ P＜0�05）；＞60岁者的β2⁃MG水平高于≤60岁的患者（ P＜0�05）；有全身症状（ B症状）组LDH水平明显高于无B症状组（ P＜0�05）；LDH和β2⁃MG水平均与性别无关。治疗有效患者化疗后LDH、β2⁃MG水平较化疗前下降，差异有统计学意义（ P＜0�05）。结论联合检测血清LDH和β2⁃MG水平可作为判断DLBCL患者的临床分期、是否存在骨髓浸润及评价疗效的临床指标。