长非编码RNA在胃癌发生发展中的研究进展

摘要

胃癌是恶性肿瘤中造成癌症相关死亡的主要原因之一，其发病机制、化疗耐药、早期诊断及预后判断等诸多问题的研究尚不明确。长非编码RNA（ lncRNA）通过复杂的分子信号网络广泛地参与了肿瘤的发生、发展过程。近年来，许多lncRNA在胃癌中的作用不断被发现证实，特别是在胃癌细胞增殖迁移、耐药发生、发现新型肿瘤标志物以及判断预后等方面。本文结合国内外在该领域的最新研究进展作一综述。%Gastric cancer(GC), as the most common malignancy, is one of the major causes of cancer⁃related mortality worldwide. While the molecular mechanisms of GC, chemoresistance, early diagnosis and clinical outcome are still poorly understood. Recent studies have demonstrated that long non⁃coding RNAs( lncRNAs) are closely associated with the development and progression of various cancers, especially in GC. Dysregulation of lncRNAs is closely related to GC cell proliferation, metastasis, drug resistance, tumor marker discovering and prognosis prediction. The aim of this review is to discuss current and emerging lncRNA in GC.