FAT10、NF-κB p50在乳腺浸润性导管癌中的表达及其临床意义

摘要

目的 探讨双泛素(FAT10)和核因子-κB p50(NF-κB p50)在乳腺浸润性导管癌中的表达及其与临床病理特征的关系.方法 应用Max VisionTM免疫组织化学法,检测112例乳腺浸润性导管癌组织和53例癌旁组织中FAT10与NF-κB p50的表达,并分析两者表达的相关性及其与乳腺癌临床病理特征的关系.结果 FAT10和NF-κB p50在乳腺浸润性导管癌中的阳性表达率分别为77.68%(87/112)和81.25%(91/112),明显高于癌旁组织的39.62%(21/53)和45.28%(24/53),差异均有统计学意义(P<0.001).FAT10、NF-κB p50在乳腺浸润性导管癌中的表达与淋巴结转移、远处转移及TNM分期有关(P<0.05),而与患者的年龄、肿瘤大小及分子分型无关(P>0.05).FAT10与NF-κB p50在乳腺浸润性导管癌中的表达呈显著正相关(r=0.624,P<0.001).结论 FAT10、NF-κB p50的表达与乳腺浸润性导管癌的恶性程度及侵袭转移密切相关,两者可能共同促进肿瘤的发生发展.%Objective To investigate the expression of human leukocyte antigen F-associated transcript 10 ( FAT10) and nu-clear factor κB p50( NF-κB p50) in infiltrating ductal carcinoma of breast, and their relationship with clinicopathological characteris-tics. Methods FAT10 and NF-κB p50 expression in 112 patients with infiltrating ductal carcinoma of breast and in 53 breast non-can-cerous tissues were measured by immunohistochemistry. The relationship between FAT10, NF-κB p50 expression and clinicopathological features of infiltrating ductal carcinoma of breast were analyzed. Results The positive rate of FAT10 and NF-κB p50 expression in infiltrating ductal carcinoma of breast was 77. 68%(87/112) and 81. 25%(91/112) respectively, significantly higher than 39. 62%(21/53)and 45. 28%(24/53)in the non-cancerous tissues,and the difference was statistically significant (P<0. 001) . The expression of FAT10, NF-κB p50 was related to lymph node metastasis, distant metastasis and TNM stages of infiltrating ductal carcinoma of breast( P<0. 05) . But they had no obvious relation to age, tumor size and molecular type( P>0. 05) . The expres-sion of FAT10 was positively correlated with the expression of NF-κB p50(r=0. 624,P<0. 001). Conclusion The expression of FAT10, NF-κB p50 is closely associated with malignancy and invasive metastasis of infiltrating ductal carcinoma of breast. They may together promote tumor's occurrence and development.