5-氨基酮戊酸在光动力和声动力治疗肿瘤中的实验与临床研究进展∗

摘要

5-氨基酮戊酸（5-aminolevulinic acid，5-ALA）作为光敏剂、声敏剂已广泛应用于光动力疗法和声动力疗法中。5-ALA 通过细胞内代谢产生原卟啉Ⅸ（Protoporphyrin Ⅸ，PpⅨ），其具有的光敏性和声敏性可以在激光和超声作用下激活，产生氧自由基或活性氧物质，诱导细胞凋亡、坏死。本文就近年来5-ALA 在光、声动力疗法治疗肿瘤中的实验与临床研究进展作一综述。%5-aminolevulinic acid(5-ALA) is a strong photosensitizer, and it is widely used in photodynamic and sonodynamic therapy. 5-ALA is a precursor of PpⅨ which is generally accumulated higher in tumor cells than normal cells. Irradiation and ultra-sound irradiation excitate PpⅨ in tumor cells and produce reactive oxygen species(ROS), and damage DNA, mitochondria membrane and the other cell membrane then causes the apoptosis, necrosis. This article reviews the experimental and clinical research progression of 5-ALA in photodynamic and sonodynamic therapy of tumor recent years.