脉压及尿微量白蛋白/肌酐与老年单纯收缩期高血压患者脉搏波传导速度

摘要

目的:探讨脉压及尿微量白蛋白/肌酐(UACR)与老年单纯收缩期高血压患者主动脉脉搏波传导速度(PWV)的关系.方法:老年单纯收缩期高血压(ISH)患者354例,进行血压、生化指标及UACR测定,应用自动脉搏波传导速度分析仪检测颈-股动脉PWV.将患者分为脉压>60 mmHg(1 mmHg=0.133 kPa)和≤60 mmHg两部分进行分析.按照UACR三分位切点值分三组,UACR<10.34 mg/g组、UACR(10.34~25.60)mg/g组、UACR>25.60 mg/g组,每组118例.结果:①脉压>60 mmHg患者的颈-股动脉PWV比脉压≤60 mmHg患者高(P<0.01),差异有统计学意义.②随UACR值由低到高,三组患者颈-股动脉PWV值逐渐增高,差异有统计学意义(P 60 mmHg and pulse pressure s=60 mmHg. ②UACR <10. 34 mg/g group,UACR =( 10. 34-25. 60 )mg/g group and UACR > 25. 60 mg/g group,n= 118 in each group.Results: ①The patients with pulse pressure >60 mmHg had higher carotid-femoral PWV than those with pulse pressure ≤ 60 mmHg,P<0. 01. ②With increased UACR, the patient' s carotid-femoral PWV elevated accordingly, P<0. 05.③Multiple stepwise regression analysis showed that the age, pulse pressure, UACR and duration of hypertension were positively related to carotid-femoral PWV, P<0. 05 respectively.Conclusion: Pulse pressure and UACR are both related to aortic PWV in elder patients with isolated systolic hypertension.