Objective: To study the correlation between angiotensin II type1 receptor autoantibodies (AT1-AAs) and the onset risk in patients with essential hypertension (EH) combiningacute coronary syndrome (ACS). Methods: Our research included in 4 groups: EH+ACS group,n=28, ACS group, n=29, EH group,n=26 and Control group,n=23 normal subjects. Serum levels of AT1-AAs were examined by ELISA; high sensitivity C-reactive protein (hs-CRP), blood levels of lipids and glucose were also measured and compared among different groups. The correlations between AT1-AAs and blood lipids, glucose, hs-CRP were studied by multiple linear regression analysis. Results: Compared with Control group, ACS group had similar level of AT1-AAs (0.26±0.09) vs (0.21±0.06),P=0.105; while EH+ACS group and HE group had increased AT1-AAs level as (0.40±0.005) and (0.33±0.10),P=0.001 andP=0.02 respectively; AT1-AAs level was higher in EH+ACS group than HE group,P=0.044. In addition, serum AT1-AAs level was positively related to hs-CRP in EH+ACS group, ACS group and EH group (r=0.589,r=0.503 andr=0.273, allP<0.01). Conclusion: Serum AT1-AAs level was positively related to the onset risk in patients with EH combining ACS; AT1-AAs was also related to hs-CRP at certain degree.%目的:探讨抗血管紧张素II 1型(AT1)受体自身抗体(AT1-AAs)与原发性高血压患者合并急性冠状动脉综合征(ACS)的发病风险.方法:收集高血压合并ACS患者(高血压+ACS组)28例、单纯ACS患者(ACS组)29例、单纯高血压患者(高血压组)26例及正常对照组23例,采用酶联免疫吸附法对标本血清进行抗AT1受体抗体检测,分析并比较各组间AT1-AAs及血清超敏C反应蛋白(hs-CRP)、血脂、血糖等水平,进一步通过多元线性回归分析各组间AT1-AAs与血脂、血糖及炎症因子血清hs-CRP表达的相关性.结果:ACS组患者血清AT1-AAs水平较正常对照组升高(分别为0.26±0.09,0.21±0.06,P=0.105),但差异未达统计学意义;而高血压+ACS组(0.40±0.05)及高血压组(0.33±0.10)其血清AT1-AAs水平则显著高于正常对照组(P=0.01和0.02)同时高血压+ACS组也明显高于高血压组(P=0.044).另外,在除正常对照组外高血压+ACS组、ACS组及高血压组中AT1-AAs水平与血清hs-CRP的表达呈正相关(r分别为0.589、0.503、0.273,P均<0.01).结论:AT1-AAs与高血压合并ACS患者的发病风险呈正相关,尤其与炎症因子血清hs-CRP水平呈一定相关性.
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