Objective To observe curative effect of deoxynucleotide combined with recombinant human granulocyte colony-stimulating factor in treatment of leukopenia after chemotherapy for gastric cancer.Methods A total of 60 moderate and advanced gastric cancer patients receiving oxaliplatin combined with docetaxel for chemotherapy were randomly divided into treatment group and control group, with 30 cases in each group. The control group received recombinant human granulocyte colony-stimulating factor for low leucocyte level during chemotherapy, and the treatment group received additional deoxynucleotide injection. Curative effects of the two groups were observed.Results Blood routine examination was taken after 3 d of chemotherapy withdrawal. The treatment group had much less cases with leucopenia as 6.67% (2/30) than 36.67% (11/30) of the control group, and their difference had statistical significance (P<0.05). Incidence of liver function impairment was obviously lower in the treatment group than in the control group, and their difference had statistical significance (χ2=4.336, P<0.05). The treatment group had slighter severity of liver function impairment, and its improvement of life quality was better than the control group (P<0.05).Conclusion Implement of deoxynucleotide combined with recombinant human granulocyte colony-stimulating factor in chemotherapy can provide more precise effect in preventing leucopenia than single use of recombinant human granulocyte colony-stimulating factor.%目的 观察脱氧核苷酸钠联合重组人粒细胞集落刺激因子治疗胃癌患者化疗所致白细胞减少的疗效.方法 60例中晚期胃癌患者均给予奥沙利铂联合多西他赛化疗, 随机分为治疗组和对照组, 各30例.对照组在化疗期间检测白细胞水平低于正常范围时给予重组人粒细胞集落刺激因子, 治疗组在此基础上加用脱氧核苷酸钠注射液.观察两组治疗效果.结果 停用化疗药3 d后复查血常规, 治疗组白细胞下降例数占6.67%(2/30), 明显少于对照组36.67%(11/30), 差异有统计学意义(P<0.05), 治疗组出现肝功能损伤的几率明显低于对照组, 差异有统计学意义(χ2=4.336,P<0.05), 且出现肝功能损伤程度较轻.治疗组生活质量改善优于对照组(P<0.05).结论 在肿瘤化疗过程中同时加用重组人粒细胞集落刺激因子和脱氧核苷酸钠预防白细胞减少效果比仅使用粒细胞集落刺激因子显著.
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