低分子肝素经患肢静脉注射与皮下注射治疗下肢深静脉血栓形成的疗效比较

摘要

目的：对比观察经患肢浅静脉注射低分子肝素与皮下注射低分子肝素治疗下肢深静脉血栓形成的疗效。方法413例下肢深静脉血栓形成患者依据确诊日期随机分组,双日纳入实验组(192例),单日纳入对照组(221例)。对照组给予低分子肝素5000 U分2次皮下注射,实验组2500 U经患肢足背浅静脉注射,观察两组患者的疗效。结果实验组治疗1周内、1~2周间和2周以上3个时段治愈病例分别为97例(50.5%)、90例(46.9%)、5例(2.6%)；对照组3个时段治愈病例分别为50例(22.6%)、161例(72.9%)、10例(4.5%)；两组差异有统计学意义(P<0.05)。结论大腿根部扎止血带经患肢足背浅静脉注射药物相当于局部用药,,安全系数大,值得临床推广。%Objective To compare and observe curative effect by low molecular weight heparin by intravenous injection and subcutaneous injection in affected limb in the treatment of lower extremity deep venous thrombosis.Methods A total of 413 patients with lower extremity deep venous thrombosis were divided by admission date into experimental group (192 cases) and control group (221 cases). The control group received twice subcutaneous injection of 5000 U low molecular weight heparin, and the experimental group received acrotarsium superficial intravenous injection of 2500 U low molecular weight heparin in affected limb. Curative effects of the two groups were observed.Results The experimental group received treatment for 1 week, during 1~2 weeks, and over 2 weeks, and its healed cases were respectively 97 cases (50.5%), 90 cases (46.9%), 5 cases (2.6%) in the 3 periods, and those in the control group were 50 cases (22.6%), 161 cases (72.9%), and 10 cases (4.5%). The difference had statistical significance between the two groups (P<0.05).Conclusion Implement of tourniquet ligation and acrotarsium superficial intravenous injection in affected limb as local administration provides small possibility of low molecular weight heparin injection bleeding and high safety. This method is worthy of clinical promotion.