羟乙基淀粉联合呋塞米治疗小儿肾病综合征重度水肿的临床效果

摘要

Objective To research and investigate the clinical effect and safety of hydroxyethyl starch combined with furosemide in the treatment of severe edema in pediatric nephrotic syndrome. Methods A total of 288 children with severe edema in pediatric nephrotic syndrome were randomly divided into experimental group and control group, with 144 cases in each group. The control group received furosemide through intravenous injection, and the experimental group received additional hydroxyethyl starch. Curative effects of the two groups were observed. Results After treatment, the experimental group had higher levels of increased urine volume, and reduced abdominal girth and weight[(196.82±50.64) ml, (8.76±1.85) cm, (20.56±6.55) kg] than the control group[(168.53±45.35) ml, (6.98±1.55) cm, (18.45±5.98) kg]. Their differences all had statistical significance (P<0.05). Conclusion Combination of hydroxyethyl starch and furosemide provides precise effect in treating severe edema in pediatric nephrotic syndrome. This method is safe and reliable, and it is worthy of promotion.%目的：研究和探讨小儿肾病综合征重度水肿采用羟乙基淀粉联合呋塞米治疗的临床效果及安全性。方法288例肾病综合征重度水肿患儿，随机分为试验组和对照组，每组144例，对照组采用呋塞米静脉注射，试验组在对照组基础上加用羟乙基淀粉治疗，观察两组患儿的疗效。结果治疗后，试验组患儿的尿量增加、腹围减小、体重减轻[(196.82±50.64)ml、(8.76±1.85)cm、(20.56±6.55)kg]明显优于对照组的[(168.53±45.35)ml、(6.98±1.55)cm、(18.45±5.98)kg]，差异均具有统计学意义(P<0.05)。结论对小儿肾病综合征重度水肿给予羟乙基淀粉联合呋塞米治疗效果显著，安全可靠，值得推广。