不同时机肠内营养对重症急性胰腺炎肠源性感染的影响

摘要

目的：探讨在重症急性胰腺炎(SAP)肠源性感染治疗中，不同时机肠内营养对治疗效果的影响。方法42例SAP合并肠源性感染患者按照随机数字表法分为早期组及阶段组，每组21例。早期组在治疗早期给予肠内营养，阶段组在治疗期间给予阶段性肠内营养治疗。对比两组肠源性感染的临床治疗效果。结果两组接受治疗前白细胞计数(WBC)、C反应蛋白(CRP)及内毒素含量水平比较，差异无统计学意义(P>0.05)，但在接受治疗7 d后，早期组WBC、CRP及内毒素含量水平均明显低于阶段组，差异有统计学意义(P<0.05)。结论在SAP合并肠源性感染患者的临床治疗中，早期肠内营养可有效的提高患者肠源性感染的临床治疗效果，临床可积极应用。%Objective To investigate influence of different enteral nutrition timing on enterogenic infection of severe acute pancreatitis (SAP).Methods A total of 42 patients with SAP combined with enterogenic infection were divided by random number table into early group and stage group, with 21 cases in each group. The early group received early enteral nutrition, and the stage group received periodical enteral nutrition during treatment. Clinical effects for enterogenic infection were compared between the two groups.Results Before treatment, there was no statistically significant difference of white blood count (WBC), C-reactive protein (CRP) and endotoxin levels between the two groups (P>0.05). After receiving treatment for 7 d, the early group had much lower levels of WBC, CRP and endotoxin than the stage group, and their difference had statistical significance (P<0.05).Conclusion Early enteral nutrition can effectively improve clinical effect in treating SAP combined with enterogenic infection, and this method can be actively applied in clinic.