Objective To observe the curative effect of minor molecular heparinum natricum combined with ozagrel sodium through subcutaneous injection for acute cerebral thrombosis patients. Methods A total of 120 patients with acute cerebral thrombosis were randomly divided into treatment group and control group, and each group contained 60 cases. The treatment group received minor molecular heparinum natricum (7 d) combined with ozagrel sodium injection (14 d) through subcutaneous injection, and the control group received ozagrel sodium injection (14 d) alone. Results The treatment group had higher total effective rate as 91.7%than 76.7%of the control group, and the difference had statistical significance (P<0.01). After the treatment, neurological severity scores in 14 d had statistically significant difference between the two groups (P<0.01). There were no severe adverse reactions in the two groups during treatment. Conclusion Subcutaneous injection of minor molecular heparinum natricum combined with ozagrel sodium can provide better effect and higher safety than single ozagrel sodium injection in treating acute cerebral thrombosis. This method is worthy of clinical promotion and application.%目的：观察皮下注射低分子肝素钠联合奥扎格雷钠治疗急性脑血栓患者的疗效。方法120例急性脑血栓患者随机分为治疗组和对照组，每组60例。治疗组采用皮下注射低分子肝素钠(7 d)联合奥扎格雷钠注射液(14 d)；对照组采用奥扎格雷钠注射液单药(14 d)，观察两组间的疗效差别及治疗前后神经功能缺损程度恢复情况。结果治疗组总有效率91.7%优于对照组76.7%，差异有统计学意义(P<0.01)；两组患者治疗后14 d神经功能缺损评分比较差异有统计学意义(P<0.01)，治疗期间两组均未出现明显不良反应。结论皮下注射低分子肝素钠联合奥扎格雷钠治疗急性脑血栓效果较单用奥扎格雷钠注射液效果明显，安全性好，值得临床推广应用。
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