探究盐酸二甲双胍肠溶胶囊对2型糖尿病周围神经病变患者的氧化应激作用

摘要

Objective To investigate effect by metformin hydrochloride enteric-coated capsules for oxidative stress in type 2 diabetic peripheral neuropathy patients.Methods A total of 84 patients with type 2 diabetic peripheral neuropathy were divided by random number table into research group and control group, with 42 cases in each group. The control group received nateglinide tablets for treatment, and the research group received metformin hydrochloride enteric-coated capsules for treatment. Clinical effects of the two groups were compared.Results After treatment, the research group had much higher sensory nerve conduction velocity (SNCV) and motor nerve conduction velocity (MNCV) of nervus peroneus communis and median nerve than those before treatment (P<0.05). They were also obviously higher than those in the control group (P<0.05). The research group had much lower serum methane dicarboxylic aldehyde (MDA) level (P<0.05) and higher superoxide dismutase (SOD) activity than the control group (P<0.05).Conclusion Metformin hydrochloride enteric-coated capsules can effectively inhibit oxidative stress and improve nerve conduction velocity in type 2 diabetic peripheral neuropathy patients, and it is worth clinical promotion.%目的 探究盐酸二甲双胍肠溶胶囊对2型糖尿病周围神经病变患者的氧化应激作用.方法 84例2型糖尿病周围神经病变患者, 依据随机数字表法分为研究组和对照组, 各42例.对照组患者给予那格列奈片治疗, 研究组患者给予盐酸二甲双胍肠溶胶囊治疗.比较两组临床疗效.结果 治疗后, 研究组患者腓总神经及正中神经感觉传导速度(SNCV)及运动传导速度(MNCV)均显著高于治疗前(P<0.05), 且显著高于对照组(P<0.05), 血清丙二醛(MDA)水平显著低于对照组(P<0.05), 超氧化物歧化酶(SOD)活性显著高于对照组(P<0.05).结论 盐酸二甲双胍肠溶胶囊能够有效抑制2型糖尿病周围神经病变患者的氧化应激反应, 并显著提高患者的神经传导速度, 值得临床推广.