双黄连与 3种不同药物配伍前、后微粒的变化

摘要

OBJECTIVE： To observe the changes of insoluble particles of shuanghuanglian in quantity after mixed with benzylpenicillin,cefradine and dexamethasone in normal saline.METHODS： Using ZWF-4D particle counter,the number of insoluble particles in sizes of ≥ 2.0μ m,≥ 5.0μ m,≥ 10.0μ m and ≥ 25.0μ m was counted and compared before and after mixed with above-mentioned three drugs.RESULTS： The insoluble particles of Shuanghuanglian were obviously increased after mixed with benzylpenicillin,the particles in sizes of ≥ 5.0μ m,≥ 10.0μ m and ≥ 25.0μ m increased twice,23 and 94 times respectively.The insoluble particles were also increased after mixed with cefradine or dexamethasone,however,the increase rate was lower in comparison with that mixed with benzylpenicillin.CONCLUSION： Shuanghuanglian,used in combination with above-mentioned drugs,should be put into separate infusion bottle to avoid the increase of insoluble particles and ADRs.%目的：考察双黄连与青霉素、头孢拉定、地塞米松 3种不同注射剂配伍前、后的不溶性微粒变化。方法：利用 ZWF-4D型注射液微粒分析仪分别计数双黄连与 3种注射剂配伍前后≥ 2 0、≥ 5 0、≥ 10 0和≥ 25 0μ m的微粒数，并进行比较。结果：双黄连与青霉素配伍后的不溶性微粒数明显多于配伍前，≥ 5 0μ m、≥ 10 0μ m、≥ 25μ m分别增加 2、 23、 94倍，而头孢拉定、地塞米松与双黄连配伍后的不溶性微粒也明显多于配伍前，但低于青霉素与双黄连配伍后的不溶性微粒数。结论：临床在用双黄连与这些药物联合应用时，宜分别放入 2个输液瓶内应用，以避免不溶性微粒数的增加及不良反应发生率的上升。