复方核酸颗粒剂的研制与疗效观察

摘要

OBJECTIVE： The compound nucleic acid granules were prepared， observed for their therapeutic effects， and determined for their pharmacological actions METHODS： Quality control was used in their preparation The therapeutic effects were observed on 22 patients with coronary heart disease of stable angina pectoris with hyperlipemia who were chosen according to clinical diagnosis standard RESULTS： （ 1） Improvment of clinical symptoms for angina pectoris： satisfactory 22 7％ ， improved 68 2％ ， failure 9 0％ ； （ 2） Blood lipid analysis： cholesterols and triglycerides were improved significantly after administration of the preparation（ P0.05;P<0.01).CONCLUSION:The compound nucleic acid granules have marked effects on coronary heart disease, angina pectoris and hyperlipemia.%目的：通过复方核酸颗粒剂的研制及临床疗效观察，确定其药理作用。方法：采用质控标准，制备药品；按临床诊断标准筛选 22例冠心病、稳定型心绞痛伴有高血脂的患者，进行疗效观察。结果：（ 1）心绞痛临床症状改善情况：显效 22 7％，有效 68 2％，无效 9 0％；（ 2）血脂分析：胆固醇及甘油三酯用药后均有显著改善（P<0.05及P〈0.01）。结论：复方核酸颗粒剂有显著的抗冠心病、心绞痛及降血脂作用。