OBJECTIVE: To discuss the severe liver function damage induced by antituberculostics.METHODS: The severe liver function damage induced by antituberculotis was analyzed in 50 patients admitted into this hospital from January 1995 to January 2000.RESULTS: Sever liver function damage was related to the following factors:(1)history of liver diseases;(2)aged patient and malnutritional patient;(3)chronic alcoholism;(4)combined use of isoniazid,rifampin with other drugs;(5)hepatic dysfunction before treatment.CONCLUSION: The abovementioned factors should be under consideration in choice of antituberculotics.%目的:探讨抗结核药物致严重肝功能损害的不良后果 。方法:对我院1995年1月~2000年1月住院病人中因抗结核药物 所致的严重肝功能损害50例进行分析。结果:严重肝功能损害 与以下因素有关:(1)既往有肝病史;(2)老年患者及营养 不良患者;(3)慢性嗜酒者;(4)异烟肼、利福平与其它药 物合用者;(5)治疗前肝功能异常者。结论:在选择抗结核 药物治疗时必须慎重考虑上述因素。
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