石墨炉原子吸收分光光度法测定阿莫西林胶囊中微量铅、镉的含量

摘要

OBJECTIVE: To establish method for the content determination of trace lead and cadmium in Amoxicillin capsules.METHODS: Graphite furnace atomic absorption spectrometry (GFAAS) was adopted. The determination wavelength was set at 283.3 nm for lead, 228.8 nm for cadmium. The lamp current was 2.0 mA and the slit-width was 0.4 nm. RESULTS: The linear range of was 0～10.0 ng·mL-1 for lead and 0～0.5 ng·mL-1 for cadmium. The average recoveries were 98.0％ (RSD=1.0％, n=9) and 97.8％ (RSD=0.99％, n=9), respectively. CONCLUSION: GFAAS is accurate, simple and sensitive for content determination of lead and cadmium in Amoxicillin capsules.%目的:建立测定阿莫西林胶囊中微量铅、镉的方法.方法:采用石墨炉原子吸收分光光度法.检测波长铅为283.3 nm,镉为228.8nm;灯电流为2.0 mA;狭缝宽度为0.4 nm.结果:铅浓度在0～10.0 ng·mL,镉浓度在0～0.5ng·mL范围内与吸光度呈良好线性关系;平均加样回收率分别为98.0%(RSD=1.0%,n=9)、97.8%(RSD=0.99%,n=9).结论:石墨炉原子吸收分光光度法测定阿莫西林胶囊中微量铅、镉,方法准确、简单、灵敏,被测溶液稳定性好.