目的:研究我院药品不良反应(ADR)发生的特点及规律,为临床安全、合理用药提供参考.方法:收集2010年我院上报给山东省ADR监测中心的639例ADR报告,分别从患者性别、年龄、给药途径、涉及药品种类以及ADR临床表现等方面进行统计并分析.结果:639例ADR报告中60岁以上老年患者较多,占34.90%;由抗微生物药导致的ADR最多,占32.25%;以静脉滴注方式为主,占81.48%;ADR累及器官或系统以皮肤及其附件损伤最为常见,占30.90%.结论:临床应重视ADR监测和报告工作,尤其是合理使用抗菌药物,以减少ADR发生.%OBJECTIVE: To study on the characteristics and regulations of adverse drug reaction (ADR) in our hospital and to provide reference for safe and rational use of drugs in the clinic. METHODS: 639 ADR reports collected from our hospital reported to Shandong ADR monitoring center in 2010 were analyzed statistically in terms of patients' gender, age, route of administration, drug variety and clinical manifestations, etc. RESULTS: Of total 639 cases, most were senile patients aged above 60 years old, accounting for 34.90%. Most of ADR were induced by antibacterials, accounting for 32.25%; most of ADR were induced by intravenous dripping, accounting for 81.48%; the most common clinical manifestations were the damage of skin and appendants, accounting for 30.90%. CONCLUSION : Importance should be attached to ADR report and monitoring. Rational use of antibacterials should be emphasized to reduce the occurrence of ADR.
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