负荷剂量氯吡格雷治疗短暂性脑缺血发作的疗效观察

摘要

OBJECTIVE: To observe the therapeutic efficacy and safety of loading dose of clopidogrel on transient ischemic attack (TIA). METHODS: 108 TIA patients were randomly divided into loading dose group and standard dose group. The former group, 58 TIA patients, was given first dose of 300 mg clopidogrel on the basis of routine therapy, while the latter group, 50 TLA patients, was given first dose of 75 mg clopidogrel on the basis of routine therapy orally. After 24 hours, they were all given maintenance dose 75 mg-d '. The platelet aggregation rate was observed before medication and 2 h, 5 h, 10 h after medication, and therapeutic efficacy and safety of 2 groups were compared. RESULTS: The therapeutic efficacy of loading dose group was better than standard dose group, there was statistical significance between 2 groups (P<0.05). The life-threatening hemorrhage cases had not found during treatment CONCLUSION: On the basis of conventional treatment, TIA patients in both groups are controlled to varying extents after conventional therapy with clopidogrel. Loading dose of clopidogrel treatment may achieve good effects.%目的:观察负荷剂量氯吡格雷治疗短暂性脑缺血发作(TIA)的疗效及安全性.方法:108例TIA患者,随机分为负荷剂量组和常规剂量组.负荷剂量组58例,在常规治疗的基础上给予首剂氯吡格雷300mg,24 h后维持75 mg·d-1治疗；常规剂量组50例,在常规治疗的基础上给予氯吡格雷75 mg·d-1,2组均用药14d.观察服药前、服药后2、5、10h2组患者血小板聚集率及服药后2组的疗效及安全性.结果:负荷剂量组的疗效显著优于常规剂量组,2组比较差异有统计学意义(P＜0.05)；2组用药后血小板聚集率均显著低于治疗前(P＜0.05),且负荷剂量组显著低于同期常规剂量组(P＜0.05).治疗过程中未见有危及生命的出血现象.结论:2组患者在常规治疗的基础上加用氯吡格雷均可使患者TIA得到不同程度的控制,但采用负荷剂量氯吡格雷治疗可取得更好效果.