某基层医院超说明书用药情况的横断面调查

摘要

OBJECTIVE:To provide reference for the clinical rational drug use. METHODS:Cross-sectional survey was adopt-ed to statistically analyze the off-label use of inpatient(489 prescriptions)and outpatient prescriptions(466 prescriptions)in our hos-pital in Jun. 19,2014. RESULTS:The prescription items and ratios of off-label use in inpatients and outpatients in our hospital were 240,14.1%(240/1 704)and 149,17.4%(149/852),respectively. The top 4 types of drug off-label use included changing ad-ministration frequency,indications,compatibility concentrations of injections and dosage. CONCLUSIONS:Some of off-label use are rational,supporting by kinds of guidelines,expert consensus and literature reporting;while some are irrational,clinic should avoid this kind of irrational use and be strictly controlled by pharmacists. Meanwhile,it is suggested that the drug manufacturers up-date the instructions timely to provide reference for ensuring safety drug use of patients.%目的:为促进临床合理用药提供参考.方法:采用横断面调查方法,对我院2014年6月19日所有住院及门诊患者的住院医嘱(489份)、门诊处方(466份)中出现的超说明书用药情况进行统计分析.结果:调查当天我院住院、门诊的超说明书用药医嘱条目数及比率分别为240、14.1%(240/1 704)和149、17.4%(149/852).超说明书用药类型方面,改变给药频次、改变适应证、改变注射液配伍浓度、改变给药剂量排前4位.结论:超说明书用药有些属于合理用药,有各类指南、专家共识及文献报道支持;有些属于不合理用药,临床应避免这类不合理用药,药师审方时应严格把关.同时,建议药品生产企业及时更新药品说明书,为保障患者用药安全提供依据.