参芪降糖颗粒辅助治疗2型糖尿病性膝关节炎的临床观察

摘要

OBJECTIVE:To observe the efficacy and safety of Shenqi jiangtang granule in the adjuvant treatment of type 2 dia-betes knee arthritis. METHODS:62 patients with type 2 diabetes knee arthritis were randomly divided into control group(31 cas-es) and observation group (31 cases). Control group received hypoglycemic and basic treatment for arthritis,including diet con-trol,exercise therapy and health education,as well as 0.25 g Metformin hydrochloride tablet with a meal,3 times a day + 50 mg Acarbose tablet with a meal,3 times a day,chewing;patients with arthritis pain 100 mg Aspirin enteric-coated tablet after a meal, once a day (chewing or breaking apart was prohibited). Observation group additionally received 3 g Shenqi jiangtang granule half an hour before a meal with 50 ml warm water,3 times a day. The treatment course for both groups was 6 months. Clinical effica-cy,and fasting plasma glucose(FPG),2 h postprandial blood glucose(2 h PG),glycated hemoglobin(HbA1c),interleukin-1β(IL-1β),IL-6 before and after treatment,and the incidence of adverse reactions in 2 groups were observed. RESULTS:The total effective rate in observation group was significantly higher than control group,the difference was statistically significant(P<0.05). Before treatment,there were no significant differences in the FPG,2 h PG,HbA1c,IL-1β and IL-6 between 2 groups(P>0.05). After treatment,FPG,2 h PG,HbA1c,IL-1β and IL-6 in 2 groups were significantly lower than before,and observation group was lower than control group,the differences were statistically significant(P<0.05). And there was no significant in the incidence of adverse reactions between 2 groups (P>0.05). CONCLUSIONS:Based on conventional treatment,Shenqi jiangtang granule shows obvious efficacy in the adjuvant treatment of type 2 diabetes knee arthritis.,it can reduce blood glucose and inflammation cy-tokine levels,mild symptoms of adverse reactions.%目的：观察参芪降糖颗粒辅助治疗2型糖尿病性膝关节炎的疗效和安全性。方法：62例2型糖尿病性膝关节炎患者随机分为对照组（31例）和观察组（31例）。对照组患者均给予降糖、针对关节炎的基础治疗，包括饮食控制、运动疗法及健康教育，同时口服盐酸二甲双胍片0.25 g，每日3次，餐中服用+阿卡波糖片50 mg，每日3次，餐中嚼服；关节炎疼痛患者服用阿司匹林肠溶片100 mg，每日1次，饭后口服（不可嚼碎或掰开服用）。观察组患者在对照组治疗的基础上给予参芪降糖颗粒3 g，每日3次，餐前半小时用50 ml温水冲服。两组疗程均为6个月。观察两组患者的临床疗效，治疗前后的空腹血糖（FPG）、餐后2 h血糖（2 h PG）、糖化血红蛋白（HbA1c）、白细胞介素（IL）-1β、IL-6及不良反应发生情况。结果：观察组患者总有效率显著高于对照组，差异有统计学意义（P＜0.05）。治疗前，两组患者FPG、2 h PG、HbA1c、IL-1β、IL-6水平比较，差异均无统计学意义（P＞0.05）。治疗后，两组患者FPG、2 h PG、HbA1c、IL-1β、IL-6水平均显著低于同组治疗前，且观察组低于对照组，差异均有统计学意义（P＜0.05）。两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：在常规治疗的基础上，参芪降糖颗粒辅助治疗2型糖尿病性膝关节炎的疗效显著，可降低血糖及炎症因子水平，且不良反应症状轻微。