红花黄色素治疗老年糖尿病肾病合并急性心肌梗死患者的临床观察

摘要

目的:观察红花黄色素治疗老年糖尿病肾病合并急性心肌梗死的临床疗效及安全性.方法:选取我院2013年1月-2015年6月收治的老年糖尿病肾病合并急性心肌梗死患者102例作为研究对象,按照随机数字表法分为观察组(52例)和对照组(50例).对照组患者给予抗凝,调脂,控制血糖、血压等常规治疗;观察组患者在对照组基础上加用注射用红花黄色素150 mg加入0.9%氯化钠注射液250 mL中,ivgtt,qd.两组患者均治疗2周.观察两组患者临床疗效,比较两组患者治疗前后肾功能指标[24小时微量蛋白定量(UMA)、血肌酐(Scr)、尿素氮(BUN)、血清总胆固醇(TC)、血清三酰甘油(TG)]、心功能指标[心脏射血分数(EF)、每搏输出量(SV)、心排出量(CO)、心脏指数(CI)]、炎症因子[C反应蛋白(CRP)、白细胞介素6(IL-6)、肿瘤坏死因子α (TNF-α)]和血液流变学指标(全血高切黏度、全血低切黏度、血细胞比容、纤维蛋白原、血小板凝聚率).记录两组患者不良反应发生情况.结果:观察组患者的总有效率为96.15%,显著高于对照组的88.00%,差异有统计学意义(P0.05);治疗后,两组患者肾功能指标、炎症因子、血液流变学指标显著降低,心功能指标显著升高,且治疗组患者上述指标均显著优于对照组,差异均有统计学意义(P0.05).After treatment,renal function index-es,inflammatory factors and hemorheological indexes of 2 groups were decreased significantly,while cardiac function indexes were in-creased significantly;above indicators of the observation group was significantly better than control group,with statistical significance (P<0.05).No obvious ADR was found in 2 groups.CONCLUSIONS:Safflower yellow pigment shows significant therapeutic effica-cy for elderly patients with diabetic nephropathy complicated with acute myocardial infarction,can significantly improve renal function and cardiac function,decrease inflammatory factor levels and improve hemorheological indexes with good safety.