OBJECTIVE:To establish drug use evaluation(DUE)criteria for tigecycline,and to provide reference for rational use of tigecycline. METHODS:Based on tigecycline instructions,referring to related specifications and literatures,DUE criteria for tigecycline was established. And on a basis of it,referring to DUE criteria,in retrospective study,the utilization of tigecycline in 179 inpatients of some one hospital during Nov. 2012-Oct. 2016 was evaluated and analyzed in respects of management indexes, medication indication,medication duration,medication results,etc. RESULTS:The results for DUE of tigecycline in this hospital was that the proportion of patients with consultation records was 83.2%(aiming at 100%);microbial inspection rate was 90.5%(aiming at 80%);the coincidence rate of medication indication was 98.9%(aiming at 90%);the rates of solvent selection,ad-ministration route,drug interaction,incompatibility,drug use in special populations meeting the criteria were all 100%(aiming at 100%);the rate of prescribing authority was 20.1%(aiming at 100%);the rate of drug dosage and medication interval meeting the criteria were 7.3%(aiming at 100%);response rate was 54.7%(aiming at 80%). CONCLUSIONS:Established DUE criteria of tigecycline can standardize the clinical utilization of tigecycline.%目的:建立替加环素药物利用评价(DUE)标准,为临床合理使用替加环素提供参考.方法:以替加环素药品说明书为基础,参照相关规范和文献,建立替加环素DUE标准;并以此为依据,采用回顾性研究方法,对某院2012年11月-2016年10月179例住院患者替加环素使用的管理指标、用药指征、用药过程、用药结果等进行综合评价分析.结果:该院替加环素DUE标准评价结果显示,病历中有会诊记录的患者比例为83.2%(目标值为100%),微生物送检率为90.5%(目标值为80%);用药指征符合标准百分率为98.9%(目标值为90%);溶剂选择、给药途径、药物相互作用、配伍禁忌、特殊人群用药符合标准百分率为100%(目标值为100%);处方权限符合标准百分率为20.1%(目标值为100%);给药剂量和给药间隔符合标准百分率为7.3%(目标值为100%);有效率为54.7%(目标值为80%).结论:本研究所建立的替加环素DUE标准可用于规范替加环素的临床使用.
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