注射用硝普钠在两种输液中的稳定性考察

摘要

Objective:To evaluate the compatible stability of sodium nitroprusside for injection ( SNP) in two kinds of solutions (5% glucose and sodium chloride injections) . Methods:A, B, C and D solution of SNP was respectively prepared according to the concentration of clinical use. The stability of SNP solution was studied in different environment with different storing time, and the as-sessment indices included the appearance, insoluble particles, pH value, ultraviolet-visible absorption spectrum and SNP content. Re-sults:The SNP solutions in 5% glucose and sodium chloride injections were stable in 26 hours in photophobic condition at 20℃ and 35℃. Under an incandescent lamp with or without lightproof, the solutions were very unstable. Conclusion:Both sodium chloride and 5% glucose injections can be used as the solvent for SNP with 26h stability. SNP injections prepared and used in clinics should be pre-served away from light to ensure the safety and effectiveness.%目的：评价注射用硝普钠在2种输液(氯化钠注射液、5%葡萄糖注射液)中的稳定性。方法：将注射用硝普钠按临床应用浓度配制成A、B、C、D四组溶液，考察不同环境条件下，不同放置时间硝普钠溶液的稳定性，包括溶液外观、不溶性微粒、pH、紫外-可见吸收光谱、硝普钠含量等。结果：在避光条件下，在20℃或35℃时，硝普钠与5%葡萄糖注射液或氯化钠注射液的配伍后26 h内是稳定的；在不用或用避光套避光且强光照射时，硝普钠溶液极不稳定。结论：氯化钠注射液和5%葡萄糖注射液均可作为注射用硝普钠的溶媒，且溶液在26 h内稳定。临床配制或使用硝普钠注射液时，要严格避光，才能保证用药安全有效。