前列康和非那雄胺治疗良性前列腺增生的对比研究

摘要

To compare the clinical effect of Qianliekang and finasteride in the treatment of benign prostatic hyperplasia to explore the effectiveness of traditional Chinese medicine for the therapy of benign prostatic hyperplasia. Methods:Totally 36 Wistar rats were selected, and then divided into 3 groups randomly with 12 ones in each, namely Qianliekang group, finasteride group and the control group. After 14 days of castration, the three groups were all treated with subcutaneous injection of 5 mg kg-1 testosterone propi-onate, and Qianliekang group was additionally treated with intragastric administration at 10-fold adult dose, finasteride group was trea-ted with intragastric administration at the dose of 0. 1 mg·kg-1 , and the control group was treated with the same amount of distilled water. The rats were sacrificed after the 21-day treatment, and the wet weight of prostate was determined, the prostate volume was measured and the pathological changes in prostate tissue were observed under a light microscope. Results:The wet weight of prostate in Qianliekang group and finasteride group was (0. 467 ± 0. 061) g and(0. 408 ± 0. 058) g, respectively, the prostate volume was (0. 371 ± 0. 059)ml and(0. 365 ± 0. 054)ml, respectively, and the above indicators were significantly lower than those in the control group(P<0. 05). Conclusion:Qianliekang can effectively inhibit benign prostatic hyperplasia in the model rats, and the mechanism may be related to the proliferation inhibition of prostate cells.%目的：：比较前列康和非那雄胺治疗大鼠良性前列腺增生的疗效。方法：36只Wistar大鼠随机分成3组,去势14 d后皮下注射丙酸睾丸酮5 mg·kg-1,前列康组按成人剂量10倍剂量灌胃给药,非那雄胺组按0.1 mg·kg-1灌胃给药,对照组给予等量的蒸馏水,21 d后处死,称取前列腺湿质量,量取前列腺体积,光镜观察前列腺组织病理学改变。结果：前列康和非那雄胺组大鼠前列腺湿质量分别为(0.467±0.061)g,(0.408±0.058)g；大鼠前列腺体积分别为(0.371±0.059)ml,(0.365±0.054)ml,均显著低于对照组大鼠(P<0.05)。结论：前列康能显著抑制模型大鼠的良性前列腺增生,其机制可能是通过抑制前列腺细胞的增殖而实现的。