2013年医院骨科患者非甾体抗炎药物用药分析

摘要

Objective To analyze the use situation of non-steroidal anti-inflammatory drugs(NSAIDs)in the orthopedic department of the hospital during one year to provide reference for clinical rational drug use. Methods The 68 754 pieces of prescription containing NSAIDs prescribed by the orthopedic department during 2013 were performed the statistical analysis. The frequency of drug use(DDDs), average daily cost(DDC),patients distribution and disease distribution of different non-steroidal anti-inflammatory drugs were ana-lyzed. Results The DDDs of Celecoxib Capsule was highest and reached 190 782,and its DDC was also highest(14. 64);the patients using NSAIDs were mainly distributed in the age group of 56-65 years old,accounting for 24. 57% of all patients;NSAIDs were mainly used in orthopedic fractures,osteoarthritis,rheumatoid arthritis,shoulder arthritis,ankylosing spondylitis,bone tumors,etc. Conclusion The market share of the new type cyclooxygenase-2(COX-2) inhibitors is continuously expanding;in the application process of NSAIDs, the appropriate drugs should be selected according to the patient's condition and the economic status. During the medication process,the monitoring of adverse drug reactions should be paid more attention to and the occurrence of drug abuse should be prevented.%目的：统计并分析医院骨科1年来非甾体抗炎药物（NSAIDs）的使用情况，为临床合理用药提供参考依据。方法对医院2013年度骨科开具的68754张NSAIDs处方进行统计和分析，比较不同NSAIDs的用药频度（DDDs）、日均费用（DDC）、患者分布、疾病分布等。结果塞来昔布胶囊的DDDs最高，达190782，DDC最高，达14.64；使用NSAIDs的患者主要分布在56~65岁，约占24.57%；NSAIDs主要应用于骨科骨折、骨关节炎、类风湿关节炎、肩关节炎、强直性脊柱炎、骨肿瘤等疾病。结论新型环氧化物酶（COX）-2抑制剂的市场份额在不断扩大，在NSAIDs应用过程中应根据患者病情、经济情况选用合适的药物，监测药品不良反应，防止药物滥用。