Objective To observe the clinical effect of mifepristone combining misoprostol and disposable cervical dilatation rod for ter-minating 12 - 18 weeks of pregnancy. Methods 100 normal pregnant women of voluntarily requiring induced labor with the gestational age of 12 - 18 weeks in our hospital were selected. Mifepristone was orally given on 1, 2 d after admission. The disposable cervical di-latation rod was placed in the morning of 2 d and taken out in the morning of 3 d. Then misoprostone was placed in the posterior vagi-nal fornix. The effect of pregnancy termination was observed and analyzed. Results Among 100 cases, 98 cases were successful with the success rate of 98. 00% , in which 94 cases of pregnancy were successfully terminated within 24 h with the success rate of 94. 00% ; in addition, the curettage rate after pregnancy termination was 30. 00% , moreover the smaller the gestational weeks, the higher the pregnant women complete abortion rate and the less the bleeding amount. Conclusion Mifepristone combining misoprostol and disposable cervical dilatation rod for terminating 12 - 18 weeks of pregnancy has the high success rate of induced labor and is simple to operate with less adverse reactions, which is worthy of clinical reference.%目的：观察米非司酮配伍米索前列醇及一次性宫颈扩张棒终止12~18周妊娠的临床效果。方法选取自愿来医院要求引产的正常孕妇100例，孕周在12~18周，入院后第1，2天均给予口服米非司酮，第2天晨起放置一次性宫颈扩张棒，第3天晨起取出扩张棒后在阴道后穹窿处放置米索前列醇，观察终止妊娠的效果。结果成功98例，成功率为98.00%，其中24 h 内成功终止妊娠94例，成功率为94.00%；终止妊娠后清宫率为30.00%，且孕周越小完全流产率越高，出血量越少。结论米非司酮配伍米索前列醇及一次性宫颈扩张棒终止12~18周妊娠，成功率高，操作简单，不良反应较少，值得临床借鉴。
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