复方益肝灵对抗结核药物致肝损伤患者血清前白蛋白等指标的影响

摘要

目的：观察复方益肝灵胶囊对抗结核药物致肝损伤患者血清前白蛋白等指标的影响。方法选择医院收治的结核患者100例，随机分为治疗组与对照组，各50例。对照组患者给予常规抗结核治疗方案，治疗组患者加用复方益肝灵治疗。结果治疗后，两组患者的丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）水平均较治疗前显著上升（ P ＜0.05），但治疗组表达水平明显低于对照组（ P＜0.05）；两组血清前白蛋白、总蛋白均有所下降，但治疗组血清前白蛋白水平显著高于对照组（ P＜0.05）；治疗组血清总蛋白下降不明显，而对照组有显著下降（ P＜0.05）；治疗组的肝损伤率为6.00%，与对照组的10.00%相比，差异无统计学意义（ P＞0.05）。结论复方益肝灵胶囊联用抗结核药物，可有效降低抗结核药物性肝损伤发生率，且不良反应小。%Objective To observe the influence of compound Yiganling Capsules on serum prealbumin(PAB)of patients with liver dam-age induced by anti-tuberculosis drugs. Methods 100 patients were randomly divided into the treatment group and the control group, 50 cases in each group. The control group received regular treatment,the treatment group received regular treatment and compound Yiganling Capsules. Results After treatment,the levels of ALT and AST in the two groups significantly increased than before treatment ( P 0. 05). Conclusion Compound Yiganling Capsules combined with anti-tuberculosis drugs can reduce the liver damage induced by anti-tuberculosis drugs with less adverse reactions.