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METHOD FOR ASSESSMENT OF MYCOBACTERIUM TUBERCULOSIS MEDICINAL SENSITIVITY BASED ON RESULTS OF BLOOD IMMUNOLOGICAL INDICES DETERMINATION IN PATIENT WITH PULMONARY TUBERCULOSIS
METHOD FOR ASSESSMENT OF MYCOBACTERIUM TUBERCULOSIS MEDICINAL SENSITIVITY BASED ON RESULTS OF BLOOD IMMUNOLOGICAL INDICES DETERMINATION IN PATIENT WITH PULMONARY TUBERCULOSIS
FIELD: medicine.;SUBSTANCE: method for assessment of Mycobacterium tuberculosis medicinal sensitivity of based on the results of blood immunological indices determination in a patient with pulmonary tuberculosis includes a blood test in which the absolute amount of phagocytic granulocytes and T lymphocytes expressing the HLA-DR-Ag late activation marker is established. The results are calculated by the formula Y=1.76-5.08X1-0.17X2, where X1 is CD3+HLA-DR+(109/liter), X2 is the number of phagocytic granulocytes (109/liter). At a value of Y1, a conclusion is made about the medicine-sensitive isolates of the tuberculosis causative agent, and at Y≥1 - about isolates without medicinal sensibility.;EFFECT: application of this invention allows to assess Mycobacterium tuberculosis medicinal sensitivity without performing bacteriological tests, which reduces the variability of data between the test samples.;4 ex
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