目的：观察蝎肽抗菌凝胶治疗深Ⅱ度烧伤的疗效并评价其安全性。方法将86例深Ⅱ度烧伤患者按随机数字表法均分为对照组和观察组。常规清创、削痂、抗感染等处理后，对照组采用磺胺嘧啶银乳膏局部覆盖，观察组使用蝎肽抗菌凝胶，疗程至创面愈合。结果观察组创面愈合效率及完整愈合时间明显优于对照组（ P﹤0.05）。治疗前两组创面细菌感染率间差异不明显（ P﹥0.05），治疗后第3天及第7天，对照组创面细菌感染率显著高于观察组（ P﹤0.05）。治疗过程中，对照组疼痛视觉模拟评分( VAS )显著高于观察组（ P﹤0.05）。对照组总不良反应发生率为30.23%，明显高于观察组的11.63%（ P﹤0.05）。结论蝎肽抗菌凝胶治疗深Ⅱ度烧伤疗效显著，且用药相对安全，值得临床推广。%Objective To observe the curative effect and safety evaluation of scorpion peptides antibacterial gel in treating deep second degree burn patients. Methods 86 cases of deep second degree burn were randomly divided into two groups. The control group was treated by sulfadiazine silver gel and the observation group was treated by scorpion peptides antibacterial gel. The wound healing effi-ciency, complete healing time of wounds, and the results of bacterial culture of the two groups were observed, and the VAS score were observed while dressing wounds. Results The wound healing efficiency and complete healing time of the observation group were signifi-cantly better than those of the control group ( P ﹤ 0. 05 ) . Before treatment, the difference of wound infection rate between the two groups was not significant( P ﹥ 0. 05), but on the 3rd day and 7th day after treatment, the wound infection rate of the control group was sig-nificantly higher than that in the observation group, the difference was statistically significant ( P ﹤ 0. 05 ) . The VAS score during the treatment in the control group was significantly higher than that in the observation group, the difference was statistically significant ( P ﹤ 0. 05 ) . The total adverse reaction rate in control group was higher than that in the observation group ( 30. 23% vs. 11. 63% ) , the difference was statistically significant ( P ﹤ 0. 05 ) . Conclusion The curative effect of scorpion peptide antibiotic gel in treating deep II degree burn is remarkable, and the process of treatment is relatively safe and it is worth of promotion.
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