海藻酸钠微球血管栓塞剂治疗多发性子宫肌瘤100例疗效及安全性评价

摘要

目的：观察海藻酸钠微球血管栓塞剂用于多发性子宫肌瘤介入术后患者的临床疗效并评价其安全性。方法选取医院收治的患者200例，采用随机数字表法分为对照组和观察组，各100例。对照组患者给予传统手术治疗，观察组患者给予海藻酸钠微球血管栓塞剂治疗。结果治疗后3，6个月，观察组的总有效率均明显高于对照组（ P﹤0.05），子宫肌瘤体积的缩小情况均明显优于对照组（ P﹤0.05）；雌二醇（E2）、促卵泡激素（FSH）、促黄体生成素（LH）改善情况均明显优于对照组（ P﹤0.05）；两组患者治疗前阴道超声窦卵泡计数( APC )未见明显差异，对照组患者治疗3个月后较治疗前未见明显差异，治疗后6个月APC计数较治疗前明显下降（ P﹤0.05）；观察组患者治疗后3，6个月APC数量较治疗前均未见明显差异（ P﹥0.05）；观察组围绝经期症状发生率为6.67%，明显少于对照组的27.50%（χ2=15.2727，P=0.0001）；两组患者不良反应发生率比较，未见明显差异（ P﹥0.05）。结论海藻酸钠微球血管栓塞剂治疗多发性子宫肌瘤，能有效缩小子宫肌瘤体积，提高近期治疗效果，降低围绝经期症状的发生率，有助于患者卵巢功能的恢复，疗效显著。%Objective To observe the clinical efficacy and safety of sodium alginate uterine artery embolization for treating multiple fi-broid. Methods Totally 200 patients admitted to the hospital were divided into the control group and the observation group according to the random number table method,100 cases in each group. The control group was given conventional surgical treatment,the observa-tion group was given sodium alginate uterine artery embolization. Results After 3,6 months of treatment,the total effective rate of the observation group was significantly higher than that of the control group( P ﹤ 0. 05);the shrink of uterine fibroid volume of the obser-vation group was significantly better than that of the control group( P ﹤ 0. 05);the E2,FSH,LH changes of the observation group were significantly lower than those of the control group( P ﹤ 0. 05);the APC between the two groups had no significant difference before treatment,the control group showed no significant difference after 3 months of treatment,and was significantly lower after 6 months of treatment than that before treatment( P ﹤ 0. 05);there was no statistically significant difference of APC in the observation group after 3,6 months of treatment( P ﹥ 0. 05). The incidence rate of menopausal symptoms of the observation group was 6. 67%,which was sig-nificantly less than 27. 50% of the control group (χ2=15. 272 7,P=0. 000 1). There was no significant difference in the incidence rate of adverse reactions between the two groups( P ﹥ 0. 05). Conclusion Sodium alginate uterine artery embolization in treating multi-ple fibroids can effectively reduce the volume of uterine fibroids,improve the therapeutic effect in the near future,reduce the periopera-tive incidence of menopausal symptoms,contribute to the recovery of ovarian function,with remarkable clinical effect.