Objective To compare the clinical efficacy of antimicrobial peptide in treating periodontitis. Methods 186 adult patients with periodontitis in the hospital form December 2013 to February 2016 were selected and divided into two groups,93 cases in each group. On the basis of the basic treatment,the control group was given tinidazole in the periodontal pocket,and the observation group was given antimicrobial peptidesin the periodontal pocket. The laque index,gingival bleeding index,depth of periodontal pocket,periodon-tal attachment level of the two groups before and after treatment were compared,and the efficacieswere evaluated. Results The plaque index,gingival bleeding index,depth of periodontal pocket,periodontal attachment level of the two groups after treatment were significant-ly lower than before treatment( P < 0. 05);the plaque index,gingival bleeding index,depth of periodontal pocket,periodontal attachment level of the observation group were significantly lower than the control group. The total effective rate of the observation group was 92. 47%,which was obviously higher than 86. 02% of the control group( P < 0. 05). Conclusion Antimicrobial peptides in treating periodontitis is more effective than tinidazole,and can improve the symptoms of periodontitis significantly,which is worthy of clinical promotion.%目的：观察抗菌肽治疗牙周炎的临床疗效。方法选取2013年12月至2016年2月成人牙周炎患者186例，按随机数字表法分为对照组和观察组，各93例。牙周炎基础治疗后，对照组患者采用替硝唑牙周袋内上药，观察组患者93例采用抗菌肽凝胶牙周袋内上药，比较治疗前后两组患者的菌斑指数、牙龈出血指数、牙周袋深度、牙龈附着水平，并评价疗效。结果两组患者治疗后的菌斑指数、牙龈出血指数、牙周袋深度及牙龈附着水平均较治疗前明显减小，且观察组均明显低于对照组（ P<0.05）；观察组患者的总有效率为92.47%，明显高于对照组的86.02%（ P<0.05）。结论抗菌肽局部用药治疗牙周炎较替硝唑效果更佳，可显著改善牙周炎症状，值得临床推广。
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