Objective To analyze 169 cases of adverse drug reactions ( ADRs ) in Zhanjiang the Second Hospital of Traditional Chinese Medicine, and to put forward targeted preventive measures. Methods Totally 100 cases of ADRs were selected from the hospital in 2015 as the pre-intervention group, and 69 cases with ADRs were chosen as the post-intervention group. The proportions of ADRs in different sex, age, drug type, route of administration and drug preparation were compared, the adverse factors associated with adverse events before intervention was analyzed. Combined with the above factors, the targeted prevention program was made. The proportions of adverse reactions in sex, age, drug type, route of administration and different drug preparations were compared before and after interven-tion. Results Before and after intervention, the children under 12 years and those over 60 years were the main groups ( P 0. 05 ) . Before and after the intervention, the skin and its appendages were the main sites of involvement ( P 0. 05 ) . Conclusion The prevention of ADRs be considered on the basis of the condition of the patients, the children and elderly patients should be given special protection, management of antimicro-bial agents and drug delivery pathways should be strengthened, the skin and its appendages and important organs should be given strengthen protection, and the targeted interventions can effectively reduce the risk of ADRs.%目的 分析湛江市第二中医医院169例药品不良反应事件,提出针对性预防措施.方法 选择医院2015年100例药品不良反应患者,作为干预前组;选择2016年69例药品不良反应患者,作为干预后组.对比不同性别、年龄段、药品种类、给药途径、不同制剂中不良反应占比,分析干预前与不良反应有关的突出因素;结合以上因素制订针对性预防方案,对比干预前后不同性别、年龄段、药品种类、给药途径、不同制剂不良反应占比.结果 干预前后12岁以下儿童和60岁以上患者是主要人群(P0.05).干预前后皮肤及其附件均是主要累及部位(P0.05).结论 预防药品不良反应应根据患者具体情况考虑,重点保护儿童及老年患者,强化抗菌药物管理和给药途径管理,加强皮肤及其附件、重要器官保护,使用针对性干预措施能有效减少或避免不良反应.
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