不同剂量开喉剑喷雾剂(儿童型)治疗手足口病临床疗效比较

摘要

目的 探讨常规剂量及大剂量开喉剑喷雾剂(儿童型)治疗普通型手足口病的临床疗效.方法 将150例普通型手足口病患儿随机分为对照组、常规剂量组及大剂量组,各50例.对照组患儿采用清热解毒中成药口服治疗,常规剂量组患儿(每日3次,每次1喷)及大剂量组患儿(每日6次,每次2喷)在对照组基础上加用不同剂量开喉剑喷雾剂(儿童型)喷口腔,观察并分析各组患儿体温、口腔疱疹消退、口腔疼痛及进食困难缓解等临床体征的变化.结果 常规组及大剂量组3 d临床显效率明显高于对照组(P<0.05);大剂量组3 d临床痊愈率及口腔疱疹减少程度明显高于对照组及常规剂量组(P<0.05).结论 开喉剑喷雾剂治疗手足口病临床疗效确切,安全可靠,大剂量使用可有效缩短病程,值得临床推广.%Objective To compare the clinical efficacy of conventional dose and large dose of Kaihoujian Spray ( for children ) in the the treatment of hand-foot-mouth disease ( HFMD ) . Methods 150 cases of HFMD patients were randomly divided into the control group, conventional dose group and high dose group, 50 cases in each group. The control group was only given oral treatment of Qingrejiedu traditional Chinese medicine;on this basis, the conventional dose group and high dose group used different doses of Kaihoujian Spray ( for children ) orally. The temperature, oral herpes reduction, clinical signs and the changes such as oral pain and dysphagia remission were observed and analyzed. Results The clinical efficacy of the conventional group and the high dose group was significantly higher than that of the control group ( P < 0. 05 ) . The clinical cure rate and oral herpes reduction rate in the high dose group were significantly higher than those in the control group and the conventional dose group ( P < 0. 05 ) . Conclusion Kaihoujian Spray has clear clinical efficacy, and is safe and reliable. The use of large dose can shorten the course of disease, which is worthy of clinical promotion.